Heliox-Driven Albuterol Nebulization for Asthma Exacerbations: An Overview

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Abstract:

Our understanding of albuterol nebulization driven by helium-oxygen mixture (heliox) has matured with recent advances in clinical therapy, delivery systems, and understanding of dosing; this has led to substantial improvements in delivery as well as refinements of research protocols for asthma exacerbations. This review begins with heliox inhalation therapy and then addresses heliox as a driving gas for nebulization. Technical considerations are reviewed, including optimal gas mixtures, flow-rate adjustment factors, and nebulizer setup.

Keywords: ALBUTEROL; ASTHMA; HELIOX; NEBULIZER; RADIONUCLIDE

Document Type: Research Article

Affiliations: 1: Division of Pediatric Emergency Medicine, Kosair Children's Hospital, University of Louisville, Louisville, Kentucky, 571 S Floyd Street, Suite 300, Louisville KY 40202;, Email: in.kim@louisville.edu 2: Division of Pediatric Emergency Medicine, Kosair Children's Hospital, University of Louisville, Louisville, Kentucky 3: Department of Pediatrics, University of Pittsburgh Medical Center, and Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 4: Division of Pulmonary, Allergy, and Critical Care Medicine, and with the Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania

Publication date: June 1, 2006

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