Noninvasive Positive-Pressure Ventilation in Patients With Milder Chronic Obstructive Pulmonary Disease Exacerbations: A Randomized Controlled Trial

The full text article is temporarily unavailable.

We apologise for the inconvenience. Please try again later.

Abstract:

OBJECTIVES: To determine the effect of the addition of noninvasive positive-pressure ventilation (NPPV) to standard medical therapy on length of hospital stay among patients presenting with mild exacerbations of chronic obstructive pulmonary disease (COPD) requiring hospitalization. DESIGN: Randomized controlled unblinded study with concealed allocation. SETTING: Respiratory ward of a single-center, academic, tertiary-care hospital. PARTICIPANTS: Patients with a prior history of COPD who presented with a recent onset of shortness of breath and a pH of > 7.30 were eligible for inclusion in the study. INTERVENTIONS: NPPV daily for 3 days for intervals of 8, 6, and 4 hours, respectively, plus standard therapy, versus standard therapy alone. MEASUREMENTS: Borg dyspnea index at baseline, 1 hour, and daily. Length of hospital stay, endotracheal intubation, hospital survival. RESULTS: We found that NPPV was generally poorly tolerated, with only 12 of 25 patients wearing it for the prescribed 3 days. With the exception of a decrease in dyspnea at 1 hour and 2 days, significant between-group differences were not seen for any measured variable. CONCLUSIONS: The effectiveness and cost-effectiveness of the addition of NPPV to standard therapy in milder COPD exacerbations remains unclear.

Keywords: BI-LEVEL POSITIVE AIRWAY PRESSURE; BIPAP; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; DYSPNEA; LENGTH OF STAY; NONINVASIVE VENTILATION

Document Type: Research Article

Affiliations: 1: Department of Medicine, Royal Columbian Hospital, New Westminster, British Columbia; the Centre for Health Evaluation and Outcome Sciences, Saint Paul's Hospital and University of British Columbia, Vancouver, British Columbia; Division of Critical Care, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Suite 103, 250 Keary Street, New Westminster, British Columbia, V3L 5E7, Canada;, Email: sean_keenan@telus.net 2: Division of Respiratory Medicine, Department of Medicine, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada

Publication date: May 1, 2005

Related content

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more