New Frontiers in Aerosol Delivery During Mechanical Ventilation

Author: Dhand, Rajiv

Source: Respiratory Care, Volume 49, Number 6, June 2004 , pp. 666-677(12)

Publisher: The Journal Respiratory Care Company

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Abstract:

The scientific basis for inhalation therapy in mechanically-ventilated patients is now firmly established. A variety of new devices that deliver drugs to the lung with high efficiency could be employed for drug delivery during mechanical ventilation. Encapsulation of drugs within liposomes could increase the amount of drug delivered, prolong the effect of a dose, and minimize adverse effects. With improved inhalation devices and surfactant formulations, inhaled surfactant could be employed for several indications in mechanically-ventilated patients. Research is unraveling the causes of some disorders that have been poorly understood, and our improved understanding of the causal mechanisms of various respiratory disorders will provide new applications for inhaled therapies.

Keywords: AEROSOL; MECHANICAL VENTILATION; VENTILATOR; LIPOSOMES; SURFACTANT; PULMONARY ALVEOLAR PROTEINOSIS

Document Type: Research article

Affiliations: 1: Division of Pulmonary, Critical Care, and Environmental Medicine, Department of Internal Medicine, MA-421 Health Sciences Center, DC043.00, 1 Hospital Drive, University of Missouri-Columbia, Columbia MO 65212;, Email: dhandr@health.missouri.edu

Publication date: 2004-06-01

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