Authors: Burton, Ray T.¹; Isaacs, Kristin K.²; Fleming, John S.³; Martonen, Ted B.⁴

Source: Respiratory Care, Volume 49, Number 2, February 2004 , pp. 180-185(6)

Publisher: The Journal Respiratory Care Company

Abstract:

A mathematical description of the morphology of the lung is necessary for modeling and analyzing the deposition of inhaled aerosols. A model of the lung boundary was generated from magnetic resonance images, with the goal of creating a framework for anatomically realistic morphological models of the human airway network. We used data visualization and analysis software to reconstruct the lung volume from a series of transverse magnetic resonance images collected at many vertical locations in the lung, ranging from apex to base. The lung model was then built using isosurface extraction techniques. These modeling methods may facilitate the creation of customized morphological models for individual subjects, resulting in improved interpretation of aerosol distribution data from single-photon-emission computed tomography (SPECT). Such customized models could be developed for children and for patients with respiratory diseases, thus aiding in the study of inhaled medications and environmental aerosols in these sensitive populations.

Keywords: MAGNETIC RESONANCE IMAGING; SINGLE-PHOTON-EMISSION COMPUTED TOMOGRAPHY; LUNG; MODELING; COMPUTER SIMULATION; MODELS; THEORETICAL; MODELS; ANATOMICAL

Document Type: Research article

Affiliations: 1: Science Applications International Corporation (SAIC) and with the United States Environmental Protection Agency Scientific Visualization Laboratory, Research Triangle Park, North Carolina 2: Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 3: Department of Medical Physics and Bioengineering, Southampton General Hospital, Southampton, United Kingdom 4: Mail Drop B-143-01, Experimental Toxicology Division, United States National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park NC 27711;, Email: martonen.ted@epa.gov

Publication date: 2004-02-01

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