Skip to main content

Analysis of degradation products in potassium dehydroandrogapholide succinate injection by HPLC-ESI/TOF-MS

Buy Article:

$20.00 + tax (Refund Policy)

Objective: To establish a high performance liquid chromatography with electrospray ionization and quadrupole-time of flight tandem mass spectrometry(HPLC-ESI/TOF-MS) method for the analysis of unknown degradation products in potassium dehydroandrographolide succinate injection. Method: Degradation products were isolated on Inertsil ODS-3 columns with mobile phase of methanol-0.2% formic acid and detected at 251 nm.Electrospray ionization(ESI) source was used at both positive and negative models. Results: Two compounds,14-deoxy-11,12-didehydroandro grapholide-3-succinate monoester and 14-deoxy-11,12-didehydroandrographolide-19-succinate monoester,were respectively identified on the basis of quasi-molecular ion peaks by HPLC-ESI/TOF-MS,along with spectroscopic methods. Conclusion: This method can be used to determine the two major degradation products in potassium dehydroandrogapholide succinate injection.

PLEASE NOTE: The full text of this publication is in Chinese.

Keywords: potassium dehydroandrogapholide succinate degradation product HPLC-ESI/TOFMS main component self-compare method impurity structure identification

Document Type: Research Article

Affiliations: 1: Sichuan Institute for Food and Drug Control Chengdu 610097 China 2: Agilent Technologies(China) Co. Ltd. Chengdu 610012 China

Publication date: 01 January 2013

More about this publication?
  • Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content