Rapid detection of caffeine content in Tankejing powder with NIR spectroscopy
Objective: Fibre optic near infrared (NIR) diffuse reflectance spectroscopy method was developed to detect rapidly caffeine content in Tankejing powder. Methods: 34 laboratory samples were prepared according to the formulation of Tankejing powder. And 31 batches of industrial samples
were collected.The contents of caffeine in Tankejing powder were determined using HPLC.Fibre optic NIR diffuse reflectance spectroscopy method was developed to determine qualitatively and quantitatively Tankejing powder. Results: For quantitative analysis,a PLS algorithm was used to construct
the multivariate calibration model.The R2and RMSECV of the calibration set were 0.975 and 0.239%(w/w),respectively.The R2 and RMSEP of the validation set were 0.926 and 0.128%(w/w),respectively.And
the mean (maximal) relative error was 1.0% (3.2%).Furthermore,a paired t-test was also performed to confirm that the NIR values and the reference values were not significantly different.The results indicated acceptable prediction accuracies for industrial on-line monitoring.For
qualitative analysis,Mahalanobis distance algorithms were utilized to construct the qualitative model which could distinguish the samples from the negative samples and those manufactured by another factory. Conclusion: The present NIR spectroscopy is rapid,simple and reliable,which can be
applied to rapid detection and on-line monirtoring of Tankejing powder.
PLEASE NOTE: The full text of this publication is in Chinese.
Keywords: Chinese patent drug; NIR; Tankejing powder; caffeine; fibre; rapid detection
Document Type: Research Article
Publication date: 01 January 2011
- Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
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