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HPLC determination of albendazole soft capsules and its related substances

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HPLC method was established for the determination of albendazoleABZsoft capsules and its related substances.Method: The column was YMCPack ODS-A (6.0 mm×150 mm,5 μm).The mobile phase consisted of 0.125% NH4H2PO4(65:35) .The flow rate was 1.0 mL·min-1.The detection wavelength was 254 nm,the column temperature at 35 .Injection volume was 10 μL.Results:The calibration curves were linear between 25.02-200.12 μg·mL-1(r=0.9999).The RSD was 1.2% for the precisionand the RSD for reproducibility was 1.5%.The average recovery was 99.8%,RSD=1.6%.The limit of detection was 12 ng and the limit of quantification was 40 ng.The solution was stable within 47 h.The related substances had been studied between new product and two old productsand the result showed bigger difference.Conclusion: The method is simple,rapid,accurateand is suitable for the determination of ABZ soft capsules and its related substances.

PLEASE NOTE: The full text of this publication is in Chinese.

Keywords: HPLC; albendazole soft capsules; determination; related substance

Document Type: Research Article

Publication date: 01 November 2008

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  • Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
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