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Preparation and application of ion selective electrode of ranolazine hydrochloride

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To establish an ion selective electrode method for the determination of ranolazine hydrochloride.Methods:A PVC membrane ranolazine hydrochloride ion selective electrode was prepared with the ion-pair of ranolazine hydrochloride-tetraphenylboron as the electroactive material and di-(2-ethylhexyl) phthalate and dibutyl phthalae as the plasticizer,and the electrode was adopted for the determination of ranolazine hydrochloride.Results:The electrode exhibited Nernst response for 1×10-5-1×10-2 mol·L-1 ranolazine hydrochloride with the slope of 55.8 mV·pC-1.The limit of detection was 4.6×10-6 mol·L-1,and the recovery was 98.5%-101.2%.The electrode performance characteristics were studied,and the electrode displayed a good selectivity for ranolazine hydrochloride in the presence of a number of foreign ions.Conclusion:The method can be adopted for determination of ranolazine hydrochloride in sustained-release tablets simply,rapidly and accurately.

PLEASE NOTE: The full text of this publication is in Chinese.

Keywords: PVC membrane; ion selective electrode; ranolazine hydrochloride

Document Type: Research Article

Publication date: 01 October 2008

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  • Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
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