Determination of residual solvents in the derivative of puerarin by capillary gas chromatography
To establish a method for determination of residual dichloromethane,acetone,ethyl acetate and pyridine simultaneously in derivative of puerarin(4ac).Methods:The residual solvents in 4ac were separated by HP-5(5% phenyl methyl siloxane) capillary column(30 m×0.53 mm×0.23
μm) with an FID detector.The carrier gas was nitrogen.The programmed column temperature was set as follows:maintained at 36 for 0.5 min and then raised to 70 at the rate of 3 ·min-1followed by holding for 1 minmaintained at 250 for 3 min of the delay time.This was followed by split
injection,where the splitting-ratio was 1:100 and the column pressure was 37.5 kPa.Result:The solvents detected were separated completely.The calibration curve of each solvent showed a good linear relationship with good precision and accuracy.Conclusion:The method is simple,rapid with
good sensitivity.It is suitable for the measurement of residual solvents in derivative of puerarin.
PLEASE NOTE: The full text of this publication is in Chinese.
Keywords: capillary gas chromatography; derivative of puerarin; multiresidue determination
Document Type: Research Article
Publication date: 01 October 2007
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