Pretreatment with a low dose of NCPP protected mice from Con A-induced liver injury and investigation of its mechanism
To investigate the effect and mechanism of pretreatment with a low dose of NCPP on concanavalin A(Con A)-induced severe liver injury.Method:On the seventh day after NCPP(0.01 mg per mouse) was injected into the peritoneal cavity of mice,Con A(25 μg·g-1)was administrated intravenously
to provoke severe liver injury models.The degree ofliver injury was estimated by serum transaminase analysis and heptatic histopathology.At the same time,set up PBS pretreatment group as negative control,8 mice per group.The number of hepatic NK cells and activation of CD4+T lymphocytes were
analyzed by flow cytometry.Result:Pretreatment with a low dose of NCPP significantly protected mice from Con A-induced severe liver injury,which were approved by the level of serum transaminase and alteration of hepatic histopathology.Accordingly, activation of hepatic CD4+T lymphocytes was
dramatically inhibited and the number of hepatic NK cells was also decreased evidently.Conclusion:Pretreatment with a low dose of NCPP protected mice from Con A-induced severe liver injury,which mainly resulted from inhibiting the recruitment of hepatic NK cells and the activation of CD4+T
lymphocytes.
PLEASE NOTE: The full text of this publication is in Chinese.
Keywords: CD4+T lymphocytes; NCPP; NK cells; concanavalin A(Con A); serum transaminase
Document Type: Research Article
Publication date: 01 July 2006
- Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
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