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Study on the quality control standardization of Guanxinjing tablets

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To establish the quality control standard of Guanxinjing tablets.Method:Rhizoma Chuanxiong,Borneolum Syntheticum,Radix Paeoniae Rubra,Radix et Rhizoma Ginseng and Radix et Rhizoma Notoginseng were identified by TLC.The content of protocatechualdehyde in Guanxinjing tablets was determined by HPLC.HIQ Sil C18column (250 mm×4.6 mm,5 μm)was used.The mobile phase was methanol-water-phosphoric acid(15:85:0.1),the detection wavelength was 278 nm,column temperature at room temperature,the flow rate was 1 mL·min-1,and the injection volume was 10 μL.Result:The calibration curve was linear in the range of 42.7-213.6 μg for protocatechualdehyde(r=0.9998,n=5).The mean recovery of protocatechualdehyde was 99.0%,RSD=2.3%.Conclusion:This method is simple,reliable,and accurate,and may be used to control the quality of Guanxinjing tablets.

PLEASE NOTE: The full text of this publication is in Chinese.

Keywords: Guanxinjing tablets; HPLC; determination; protocatechualdehyde

Document Type: Research Article

Publication date: 01 July 2006

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  • Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
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