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Research on the Interference in Determination of Residual Solvents in Pharmaceuticals by Headspace Gas Chromatography

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To research co-elution and thermal degradation which frequently interfere the determination of residual solvents in pharmaceuticals when headspace GC is used.The means of eliminating these interferences were suggested.Methods: Research co-elution in determination of residual solvents in pirarubicin and cefalexin using different polarity of columns.Research the thermal degradation of pharmaceuticals which has methoxy in the molecular formula using different headspace condition.Results: Using different polarity of columns can eliminate co-elution in pirarubicin and cefalexin.Pharmaceuticals which has methoxy can degrade to yield methanol if the headspace oven temperature is too high.Conclusions: Co-elution and thermal degradation should be eliminated in determination of residual solvents in pharmaceuticals when headspace GC is used.

PLEASE NOTE: The full text of this publication is in Chinese.

Keywords: co-elution; headspace gas chromatography; residual solvent; thermal degradation

Document Type: Research Article

Publication date: 01 July 2005

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  • Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
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