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Detection of Glyburide in Traditional Chinese Medicine by Liquid Chromatography-Mass Spectrometry Method

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An analytic technique using liquid chromatography(LC)coupled with electrospray-mass spectrometry(ESI-MS)has been developed for the identification of glyburide illegally added in traditional Chinese medicine preparations.Methods:The detection was performed on a C8 column with a mobile phase of acetonitrile-water-formic acid(70:30:1).The compound illegally added in traditional Chinese medicine preparations was identified according to the chromatographic behavior and mass spectral data by comparison with those of authentic standard.Results: Glyburide was found in all 6 samples.Conclusion:The method is selectivesensitive and reliablecan be used to detect the illegally added components in traditional Chinese medicine and control the quality.

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Keywords: Antidiabetics; Glyburide; LC/MSn; Traditional Chinese medicine

Document Type: Research Article

Publication date: 01 March 2005

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  • Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
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