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Determination of Zolmitriptan in Human Plasma byRP-HPLC with Liquid-liquid Extraction

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To establish a RP-HPLC method for determination of zolmitriptanZOLin human plasma.Methods:ZOL and internal standard(tinidazole,TDZ)were extracted from plasma with dichloromethane.The compounds were separated on a Hypersil C18 column(200 mm×5.0 mm5 μm).The mobile phase was a mixture of acetonitrile-0.05 mol·mL-1NaH2PO4 in a ratio of 15:85(adjusted pH to 5.0 by H3PO4)the flow rate was 1.0 mL min-1.The column temperature was room temperature.The detection wavelength was UV 223 nm.Results:A good linearity was obtained from 1.92 to 66.14 ng·mL-1in plasma.The lowest concentration detected was 1.92 ng·mL-1.The recovery of method were from 90.62%to 105.7%and recovery of extraction were from 71.70%to 114.75%.Conclusion:The mrthod is sensitivea accurate and reproducible with good recovery.

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Keywords: RP-HPLC; drug concentration in plasma; zolmitriptanZOL

Document Type: Research Article

Publication date: 01 March 2005

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  • Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
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