Spectrophotometric Determination of Azithromycin Basedon Charge-transfer Reaction with 2,4-Dinitrophenol
To establish a spectrophotometric method for the determination of azithromycinbased on charge-transfer reaction.MethodAzithromycin reacted with 2,4-dinitrophenol to form a charge-transfer complex in alcohol and can be quantitatively determined by spectrophotometric method at 364 nm.Results: The linear equation is A=34.6C-1.76×10-2relation coefficient is 0.999 5 in the range of 5-30 μg·mL-1.The average recovery was 99.3%RSD was less than 0.39%.Conclusion: The method is simplesensitive and accuratecan be used to the determination of azithromycin tablets.
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Document Type: Research Article
Publication date: 2005-03-01
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- Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
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