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Study on Relation of Dissolution of Benorilate Tablets with Drug Concentration in Human Plasma

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Study of the relation between dissolution of benorilate tablets and concentration in human plasma to establish dissolution method.Method:1% Sodium laurylsulfate solution was used as the medium,paddles method was used with sampling after 45 minutes.UV spectrophotometry was adapted for the determination of dissolution of benorilate tablets.The concentration of benorilate in human plasma was estimated by using a HPLC method which has been developed to determine the hydrodytic products of benorilate paracetamol and salicylic acid with p-dimethylaminobenzaldehyde as the internal standard.The relationship between dissolution and concentration of benorilate in human plasma was treated statistically.Results:A good relationship existed between the dissolution and pharmacokinetic parameters AUC,Cmaxr=0.968;0.985(n=5),r0.013=0.959.Conclusion:The method established for benorilate tablets dissolution can control the sample quality effectively.

PLEASE NOTE: The full text of this publication is in Chinese.

Keywords: benorilate tablets; dissolution; pharmacokinetics

Document Type: Research Article

Publication date: 01 January 2002

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  • Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
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