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QUALITATIVE INVESTIGATION OF POTASIUM ANTlMONY TARTRATE OPTICAL ISOMERS AND THE STABILITY CONSTANT

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It Was anticipated that potasium antimony tartrate occurred in four optical isomersIedextro-leavo-meso-and racemic formsThe respective forms were synthesized and their corresponding physiealchemical propertiestoxicity as well as antibilharzial activity were investigatedThe meso-and racemic compounds showed slightly different from the others in finger print region of its IR spectrumThe solubility of the meso-form in water was found to be 5-10 times of that of otherFormsNo significant differences were found in acute toxicity tests and in schistosomicidal activity in animal tests Injection of potasium antimony tartrate sometimes becomes slightly turbid on keepingThe complexing constant of potasium antimony tartrate was observed and the data indicated that the compound would show favourable stability in the form of this preparation

PLEASE NOTE: The full text of this publication is in Chinese.

Document Type: Research Article

Publication date: 01 September 1982

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  • Journal of Pharmaceutical Analysis is a professional journal administrated by China Association for Science and Technology, sponsored by Chinese Pharmaceutical Association, held by National Institutes for Food and Drug Control, edited and published by the Editorial Board of Journal of Pharmaceutical Analysis, and publicly distributed at home and abroad. It is one of the first group of journals that created by academic leaders in the field of drug control. It originated from Drug Control Communication which magazine was founded in 1951 and later been renamed in 1981. In 2005, it was changed from bi-monthly journal to monthly journal. Journal of Pharmaceutical Analysis is among core journals in nature sciences and even other Chinese core journals, whose main columns are research reports, communications, review, forum, information and etc. It mainly reports the latest research results, explore new theories, introduce new development, spread new techniques, and promote new methods of pharmaceutical analysis. Its contents include peer-reviewed research reports, research presentation and summary reviews on all aspects of pharmaceutical analysis including drug development, pharmaceutical manufacturing, clinical research, drug safety, quality assessment, and market surveillance. Main authors and target reader are professional and technical personnel engaged in research, application as well as higher education in pharmaceutical analysis.
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