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Open Access Endobronchial valve treatment of destructive multidrug-resistant tuberculosis

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BACKGROUND: In accordance with the existing hypothesis, the application of an endobronchial valve (EbV) leads to selective curative atelectasis of the affected part of the lung, contributing to early closure of cavities.

OBJECTIVE: To assess the effect of EbV treatment on the course of tuberculosis (TB).

METHODS: We compared the efficacy of EbV treatment and complex second-line treatment in treating patients with destructive pulmonary multidrug-resistant TB (MDR-TB). Bacteriological conversion and closure of cavities were selected as criteria to assess the effectiveness of EbV application. A total of 102 patients with destructive MDR-TB were enrolled into the study and randomly divided into two groups: 49 patients had an EbV installed (intervention group) and 53 patients received complex second-line treatment (control group). Complex chemotherapy was administered to both groups throughout the study period.

RESULTS: The cure rate in the short- and long-term follow-up periods in the intervention group was shown to be much higher, 95.9% by bacteriological conversion and 67.3% by cavity closure. On comparison with the control group, this was respectively 37.7% and 20.7% (P < 0.0001).

CONCLUSIONS: The application of EbV treatment can significantly improve the effectiveness of second-line chemotherapy regimens in MDR-TB patients.
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Keywords: EbV; anti-tuberculosis treatment; bronchoscopy; non-pharmacological treatment of TB

Document Type: Research Article

Affiliations: 1: Clinical Department, Novosibirsk TB Research Institute, Novosibirsk, Russian Federation 2: Scientific Department, Novosibirsk TB Research Institute, Novosibirsk, Russian Federation 3: Altai Medical State University, Operative Surgery and Topographic Anatomy Department, Barnaul, Russian Federation

Publication date: 2016-11-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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