Endobronchial valve treatment of destructive multidrug-resistant tuberculosis
OBJECTIVE: To assess the effect of EbV treatment on the course of tuberculosis (TB).
METHODS: We compared the efficacy of EbV treatment and complex second-line treatment in treating patients with destructive pulmonary multidrug-resistant TB (MDR-TB). Bacteriological conversion and closure of cavities were selected as criteria to assess the effectiveness of EbV application. A total of 102 patients with destructive MDR-TB were enrolled into the study and randomly divided into two groups: 49 patients had an EbV installed (intervention group) and 53 patients received complex second-line treatment (control group). Complex chemotherapy was administered to both groups throughout the study period.
RESULTS: The cure rate in the short- and long-term follow-up periods in the intervention group was shown to be much higher, 95.9% by bacteriological conversion and 67.3% by cavity closure. On comparison with the control group, this was respectively 37.7% and 20.7% (P < 0.0001).
CONCLUSIONS: The application of EbV treatment can significantly improve the effectiveness of second-line chemotherapy regimens in MDR-TB patients.
Document Type: Research Article
Affiliations: 1: Clinical Department, Novosibirsk TB Research Institute, Novosibirsk, Russian Federation 2: Scientific Department, Novosibirsk TB Research Institute, Novosibirsk, Russian Federation 3: Altai Medical State University, Operative Surgery and Topographic Anatomy Department, Barnaul, Russian Federation
Publication date: 2016-11-01
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