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Free Content Predominance of modern Mycobacterium tuberculosis isolates in North India [Short communication]

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Abstract:

Although India accounts for the highest tuberculosis (TB) burden in the world, the diversity in prevalent Mycobacterium tuberculosis strains is very poorly documented. Tuberculosis specific deletion 1 (TbD1) is a marker that has been used to differentiate ancient from modern strains. We report for the first time TbD1-based diversity in clinical M. tuberculosis isolates circulating in the North Indian states of Himachal Pradesh and Punjab. The present study documents a very high prevalence of modern strains in North India, which is in contrast to earlier studies that emphasised the predominance of ancestral strains for the majority of TB cases in India.

Keywords: TbD1; ancestral strains; diversity

Document Type: Research Article

DOI: http://dx.doi.org/10.5588/ijtld.13.0723

Affiliations: 1: Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar, India 2: Symmetrix Biotech, Department of Biotechnology, Institute of Microbial Technology Campus, Chandigarh, India

Publication date: February 1, 2014

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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