Skip to main content

Free Content Human toll-like receptor 1 T1805G polymorphism and susceptibility to pulmonary tuberculosis in northern Spain [Short communication]

Download Article:
 Download
(PDF 247.712890625 kb)
 
Toll-like receptors (TLRs) are key sensors of mycobacterial infections and play a crucial role in the initiation and coordination of the antimycobacterial innate immune response. T1805G, a functional TLR1 single nucleotide polymorphism (SNP), has been associated with susceptibility to pulmonary tuberculosis (PTB), but contradictory results among different populations have been reported. Our objective was to study this SNP in a genetically homogeneous population to evaluate its role in conferring susceptibility or resistance to PTB. In our population, the 1805G allele and the GG genotype (OR 2.04, 95%CI 1.26–3.31) influence susceptibility to PTB, in contrast with data observed in other populations.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: TLR1; genotype; polymorphism; pulmonary tuberculosis; susceptibility

Document Type: Research Article

Affiliations: 1: Immunology Service, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain 2: Pneumology Service, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain 3: Cantabria Regional Blood Centre, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain 4: Infectious Diseases Unit, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain

Publication date: 2013-05-01

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more