Free Content Outcomes of children treated for tuberculosis with second-line medications in Georgia, 2009–2011

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Abstract:

BACKGROUND: Drug-resistant tuberculosis (DR-TB) is a major public threat in countries of the former Soviet Union, including Georgia. There are few studies of pediatric DR-TB cases, especially at a national level.

OBJECTIVE: To report the characteristics and treatment outcomes of pediatric multidrug-resistant TB (MDR-TB) cases in Georgia.

METHODS: We extracted data on all pediatric (age <16 years) MDR-TB cases notified in Georgia from 2009 to 2011. We assessed the baseline and treatment characteristics and treatment outcomes of this cohort.

RESULTS: Between 2009 and 2011, there were 45 notified pediatric DR-TB cases in Georgia. Just over half had previously received anti-tuberculosis treatment and the median age was 7.7 years. Time from diagnosis to treatment was short (median 16 days), and the median length of treatment was 20.2 months. Of those not still on treatment, 77.1% (95%CI 61.0–87.9) had a successful outcome.

CONCLUSIONS: One of the first reports of pediatric DR-TB treatment outcomes at a national level, this study demonstrates that successful outcomes can be achieved.

Keywords: Georgia; children; multidrug-resistant TB; pediatrics

Document Type: Research Article

DOI: http://dx.doi.org/10.5588/ijtld.12.0792

Affiliations: 1: United States Agency for International Development Georgia TB Prevention Project, Tbilisi, Georgia 2: Brigham and Women's Hospital, Boston, Massachusetts, USA; and Harvard Medical School, Boston, Massachusetts, USA 3: David Agmashenebeli University of Georgia, Tbilisi, Georgia 4: TB Research Unit, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

Publication date: May 1, 2013

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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