Free Content Effect of obesity on patient-reported outcomes in sarcoidosis

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OBJECTIVES: To assess the impact of high body mass index (BMI) on patient-reported outcomes in sarcoidosis patients and healthy persons.

METHODS: In this case-control study, we investigated symptoms of fatigue and dyspnoea, health status, BMI and spirometric tests in 184 sarcoidosis patients and the same number of sex- and age-matched healthy subjects. Fatigue was assessed using the fatigue scale (FS), dyspnoea was determined by the baseline dyspnoea index (BDI) and health status was measured using the respiratory-specific St George's Respiratory Questionnaire (SGRQ).

RESULTS: There were significantly more subjects with increased BMI (≥25 kg/m2) among the sarcoidosis patients than among the healthy volunteers (2 37.675, P < 0.01). Sarcoidosis patients also had a greater probability of having a higher BMI (P < 0.01, OR 1.18, 95%CI 1.071.3). We found significantly lower BDI scores and forced expiratory volume in 1 s/forced vital capacity, as well as higher total SGRQ and total FS scores in sarcoidosis patients than in healthy individuals (P < 0.01 for all differences).

CONCLUSION: Sarcoidosis significantly reduces patients' health status, both independently and also due to increased BMI. Reduction in BMI may contribute to improved spirometry results and health status of patients with sarcoidosis.

Keywords: body mass index; dyspnoea; fatigue; health status; obesity; patient-reported outcomes; sarcoidosis

Document Type: Research Article


Affiliations: 1: Department of Clinical Management, PPD Serbia, Serbia, Belgrade, Serbia 2: Clinic for Pulmonary Diseases, Clinical Centre of Serbia, Belgrade, Serbia; and School of Medicine, University of Belgrade, Belgrade, Serbia 3: Health Center Valjevo, Quality Assurance Department, Valjevo, Serbia 4: University of Cincinnati Medical Center, Cincinnati, Ohio, USA 5: Clinic for Pulmonary Diseases, Clinical Centre of Serbia, Belgrade, Serbia

Publication date: April 1, 2013

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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