Drug resistance in Mexico: results from the National Survey on Drug-Resistant Tuberculosis
Abstract:OBJECTIVE: To present estimations obtained from a population-level survey conducted in Mexico of prevalence rates of mono-, poly- and multidrug-resistant strains among newly diagnosed cases of pulmonary tuberculosis (TB), as well as the main factors associated with multidrug resistance (combined resistance to isoniazid and rifampicin).
DESIGN: Study data came from the National Survey on TB Drug Resistance (ENTB-2008), a nationally representative survey conducted during 2008–2009 in nine states with a stratified cluster sampling design. Samples were obtained for all newly diagnosed cases of pulmonary TB in selected sites. Drug susceptibility testing (DST) was performed for anti-tuberculosis drugs.
RESULTS: DST results were obtained for 75% of the cases. Of these, 82.2% (95%CI 79.5–84.7) were susceptible to all drugs. The prevalence of multidrug-resistant TB (MDR-TB) was estimated at 2.8% (95%CI 1.9–4.0). MDR-TB was associated with previous treatment (OR 3.3, 95%CI 1.1–9.4).
CONCLUSIONS: The prevalence of drug resistance is relatively low in Mexico. ENTB-2008 can be used as a baseline for future follow-up of drug resistance.
Document Type: Research Article
Affiliations: 1: El Colegio de la Frontera Norte, San Antonio del Mar, Tijuana, Baja California, Mexico 2: Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City, Mexico 3: Centro Nacional de Programas Preventivos y Control de Enfermedades, Mexico City, Mexico 4: Instituto Nacional de Estadística y Geografía, Aguascalientes City, Mexico 5: Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City, Mexico; and Instituto Mexicano del Seguro Social, Mexico City, Mexico 6: Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico
Publication date: 2013-04-01
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