Drug resistance in Mexico: results from the National Survey on Drug-Resistant Tuberculosis
Authors: Bojorquez-Chapela, I.1; Bäcker, C. E.2; Orejel, I.3; López, A.4; Díaz-Quiñonez, A.5; Hernández-Serrato, M. I.6; Balandrano, S.2; Romero, M.6; Téllez-Rojo Solís, M. M.6; Castellanos, M.3; Alpuche, C.6; Hernández-Ávila, M.6; López-Gatell, H.6
Source: The International Journal of Tuberculosis and Lung Disease, Volume 17, Number 4, 1 April 2013 , pp. 514-519(6)
Abstract:OBJECTIVE: To present estimations obtained from a population-level survey conducted in Mexico of prevalence rates of mono-, poly- and multidrug-resistant strains among newly diagnosed cases of pulmonary tuberculosis (TB), as well as the main factors associated with multidrug resistance (combined resistance to isoniazid and rifampicin).
DESIGN: Study data came from the National Survey on TB Drug Resistance (ENTB-2008), a nationally representative survey conducted during 2008–2009 in nine states with a stratified cluster sampling design. Samples were obtained for all newly diagnosed cases of pulmonary TB in selected sites. Drug susceptibility testing (DST) was performed for anti-tuberculosis drugs.
RESULTS: DST results were obtained for 75% of the cases. Of these, 82.2% (95%CI 79.5–84.7) were susceptible to all drugs. The prevalence of multidrug-resistant TB (MDR-TB) was estimated at 2.8% (95%CI 1.9–4.0). MDR-TB was associated with previous treatment (OR 3.3, 95%CI 1.1–9.4).
CONCLUSIONS: The prevalence of drug resistance is relatively low in Mexico. ENTB-2008 can be used as a baseline for future follow-up of drug resistance.
Document Type: Research Article
Affiliations: 1: El Colegio de la Frontera Norte, San Antonio del Mar, Tijuana, Baja California, Mexico 2: Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City, Mexico 3: Centro Nacional de Programas Preventivos y Control de Enfermedades, Mexico City, Mexico 4: Instituto Nacional de Estadística y Geografía, Aguascalientes City, Mexico 5: Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City, Mexico; and Instituto Mexicano del Seguro Social, Mexico City, Mexico 6: Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico
Publication date: April 1, 2013
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- By this author: Bojorquez-Chapela, I. ; Bäcker, C. E. ; Orejel, I. ; López, A. ; Díaz-Quiñonez, A. ; Hernández-Serrato, M. I. ; Balandrano, S. ; Romero, M. ; Téllez-Rojo Solís, M. M. ; Castellanos, M. ; Alpuche, C. ; Hernández-Ávila, M. ; López-Gatell, H.