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Free Content Drug resistance in Mexico: results from the National Survey on Drug-Resistant Tuberculosis

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OBJECTIVE: To present estimations obtained from a population-level survey conducted in Mexico of prevalence rates of mono-, poly- and multidrug-resistant strains among newly diagnosed cases of pulmonary tuberculosis (TB), as well as the main factors associated with multidrug resistance (combined resistance to isoniazid and rifampicin).

DESIGN: Study data came from the National Survey on TB Drug Resistance (ENTB-2008), a nationally representative survey conducted during 2008–2009 in nine states with a stratified cluster sampling design. Samples were obtained for all newly diagnosed cases of pulmonary TB in selected sites. Drug susceptibility testing (DST) was performed for anti-tuberculosis drugs.

RESULTS: DST results were obtained for 75% of the cases. Of these, 82.2% (95%CI 79.5–84.7) were susceptible to all drugs. The prevalence of multidrug-resistant TB (MDR-TB) was estimated at 2.8% (95%CI 1.9–4.0). MDR-TB was associated with previous treatment (OR 3.3, 95%CI 1.1–9.4).

CONCLUSIONS: The prevalence of drug resistance is relatively low in Mexico. ENTB-2008 can be used as a baseline for future follow-up of drug resistance.
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Keywords: epidemiology; multidrug-resistant tuberculosis; pulmonary tuberculosis

Document Type: Research Article

Affiliations: 1: El Colegio de la Frontera Norte, San Antonio del Mar, Tijuana, Baja California, Mexico 2: Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City, Mexico 3: Centro Nacional de Programas Preventivos y Control de Enfermedades, Mexico City, Mexico 4: Instituto Nacional de Estadística y Geografía, Aguascalientes City, Mexico 5: Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City, Mexico; and Instituto Mexicano del Seguro Social, Mexico City, Mexico 6: Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico

Publication date: 2013-04-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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