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Home / The International Journal of Tuberculosis and Lung Disease, Volume 17, Number 2

Genotyping of clinical Mycobacterium tuberculosis isolates based on eight loci of MIRU-VNTR [Notes from the field]

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Genotyping that differentiates between strains of Mycobacterium tuberculosis based on variations in the genome of the organism is a useful tool for molecular epidemiological studies of tuberculosis. In the present study, we identified a combination of five mycobacterial interspersed repetitive unit (MIRU) loci and three variable numbers of tandem repeats (VNTR) loci of M. tuberculosis that showed a discriminatory power comparable to that of the 15 to 24 loci-based typing proposed for international standardisation in analysing 210 paediatric isolates obtained from Chongqing, China.

Keywords: MIRU typing; Mycobacterium tuberculosis; paediatric tuberculosis; spoligotyping

Document Type: Research Article

Affiliations: 1: Department of Infectious Diseases and Gastroenterology, and Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Paediatrics in Chongqing, Chongqing International Science and Technology Cooperation Centre for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China 2: Department of Infectious Diseases and Gastroenterology, Chongqing International Science and Technology Cooperation Centre for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China 3: Epidemiology Department, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA

Publication date: 01 February 2013

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