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Free Content Genotyping of clinical Mycobacterium tuberculosis isolates based on eight loci of MIRU-VNTR [Notes from the field]

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Abstract:

Genotyping that differentiates between strains of Mycobacterium tuberculosis based on variations in the genome of the organism is a useful tool for molecular epidemiological studies of tuberculosis. In the present study, we identified a combination of five mycobacterial interspersed repetitive unit (MIRU) loci and three variable numbers of tandem repeats (VNTR) loci of M. tuberculosis that showed a discriminatory power comparable to that of the 15 to 24 loci-based typing proposed for international standardisation in analysing 210 paediatric isolates obtained from Chongqing, China.

Keywords: MIRU typing; Mycobacterium tuberculosis; paediatric tuberculosis; spoligotyping

Document Type: Research Article

DOI: http://dx.doi.org/10.5588/ijtld.12.0777

Affiliations: 1: Department of Infectious Diseases and Gastroenterology, and Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Paediatrics in Chongqing, Chongqing International Science and Technology Cooperation Centre for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China 2: Department of Infectious Diseases and Gastroenterology, Chongqing International Science and Technology Cooperation Centre for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China 3: Epidemiology Department, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA

Publication date: February 1, 2013

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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