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Free Content Tuberculous lymphadenopathy: a multicentre operational study of 6-month thrice weekly directly observed treatment

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Abstract:

SETTING: Eight operational locations for the Revised National Tuberculosis Control Programme in six Indian states.

OBJECTIVE: To assess the 6-month efficacy of an intermittent thrice-weekly directly observed treatment (DOT) regimen for tuberculous peripheral adenopathy and the need for prolongation of treatment to 9 months for non-resolution of lymphadenopathy.

DESIGN: Patients aged >5 years with tuberculous lymphadenopathy were included in the study. Patients were evaluated for resolution at repeat visits following treatment. Those with poor resolution at 6 months were randomised to extended treatment up to 9 months or observation without additional treatment.

RESULTS: Resolution of lymphadenopathy was observed at the end of 6 months in 517/551 (93.8%) patients. There was a significant difference in response among patients with and those without the presence of systemic symptoms. There was no association between treatment response and number, size, site, consistency and matting of lymphadenopathy. No differences in response were seen in the remaining 34 patients with or without extended treatment.

CONCLUSION: The operational efficacy of 6-month thrice-weekly DOT for peripheral tubercular lymphadenopathy was satisfactory. There was no evidence of additional benefits of prolonging treatment to 9 months.

Keywords: Revised National Tuberculosis Control Programme; directly observed treatment; intermittent therapy; lymphadenopathy; tuberculosis

Document Type: Research Article

DOI: http://dx.doi.org/10.5588/ijtld.12.0333

Affiliations: 1: Department of Pulmonary Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India 2: Department of Tuberculosis and Chest Diseases, Jawarharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India 3: Department of Tuberculosis and Respiratory Medicine, Postgraduate Institute of Medical Sciences, Rohtak, India 4: Department of Pulmonary Medicine, Government Medical College Hospital, Chandigarh, India 5: Department of Pulmonary Medicine, Indira Gandhi Medical College, Shimla, India 6: Division of Pulmonary, Critical Care and Sleep Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati, India 7: Division of Chest Diseases, Dayanand Medical College Hospital, Ludhiana, India

Publication date: February 1, 2013

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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