Effectiveness of active case-finding strategies in tuberculosis control in Kampala, Uganda
METHODS: We developed a decision tree and Markov model to compare ACF vs. PCF across several outcome measures. Parameter estimates for costs, probabilities and utility scores were obtained from published reports and peer-reviewed journal articles. The main outcome measures were TB cases detected, deaths averted, life years saved (LYS) and quality-adjusted life years (QALYs).
RESULTS: Our model found that ACF implemented city-wide would result in an additional 1594 TB cases detected in 1 year, 675 deaths averted over a 5-year period, 21 928 LYS, and would cost an additional US$109 per additional QALY. The 25–34 year age group received most health benefits (556 cases detected, 229 deaths averted, 8058 LYS), and the programme was most cost-effective in the 45–54 year age group (US$51/QALY).
CONCLUSIONS: ACF is an effective strategy for TB control and improving quality of life and is also cost-effective.
Document Type: Research Article
Affiliations: 1: Department of Paediatrics and Child Health, School of Medicine College of Health Sciences, Makerere University, Kampala, Uganda 2: Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA 3: Department of Community Health, Mbarara University of Science and Technology, Mbarara, Uganda 4: Clinical Epidemiology Unit, School of Medicine Makerere University, Kampala, Uganda 5: Department of Epidemiology and Biostatistics School of Public Health College of Health Sciences, Makerere University, Kampala, Uganda
Publication date: 01 February 2013
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