Risk factors for Mycobacterium tuberculosis infection in Indonesian children living with a sputum smear-positive case
DESIGN: Child contacts of smear-positive adult TB patients were invited for Mycobacterium tuberculosis infection and disease screening by symptoms, tuberculin skin test (TST), QuantiFERON®-TB Gold In-Tube assay (QFT-GIT) and chest X-ray. Risk factors for infection were collected using a questionnaire and were calculated separately for TST, for QFT-GIT and for both tests combined.
RESULTS: Of 304 screened children 145/302 (48%) were positive using TST, 152/299 (51%) by QFT-GIT and 180/304 (59%) were positive using either or both tests. Positivity for both tests was associated with index case infectivity (acid-fast bacilli [AFB] 3+ vs. AFB 1+: TST OR 2.93, 95%CI 1.59–5.39; QFT-GIT OR 2.28, 95%CI 1.06–4.90) and exposure (child contact's parent is the index case: TST OR 7.04, 95%CI 2.23–22.28; QFT-GIT OR 4.30, 95%CI 1.48–12.45).
CONCLUSION: M. tuberculosis infection according to either test was high, supporting screening and preventive treatment. Children of smear-positive TB cases who accompany their parents to the clinic should be prioritised for immediate screening.
Document Type: Research Article
Affiliations: 1: Centre for International Health, University of Otago, Dunedin, New Zealand 2: Health Research Unit, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia 3: Bandung Community Lung Clinic, Bandung, Indonesia 4: Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Publication date: 2012-12-01
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