Free Content The impact of total antioxidant capacity on pulmonary function in asthma patients

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Abstract:

BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma.

OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients.

METHOD: A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared.

RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV1) at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV1 both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status.

CONCLUSION: These results suggest an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.

Keywords: antioxidants; asthma; oxidative stress

Document Type: Research Article

DOI: http://dx.doi.org/10.5588/ijtld.12.0842

Affiliations: 1: Division of Allergy and Clinical Immunology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea 2: Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea 3: Department of Internal Medicine, Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea 4: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea 5: Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, South Korea 6: Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, South Korea 7: Department of Internal Medicine, College of Medicine, Ajou University, Suwon, South Korea 8: Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, South Korea 9: Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, South Korea

Publication date: November 1, 2012

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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