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Free Content Retreatment tuberculosis in a South African community: the role of re-infection, HIV and antiretroviral treatment

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Abstract:

BACKGROUND: Limited data exist on the impact of human immunodeficiency virus (HIV) or antiretroviral treatment (ART) on retreatment tuberculosis (TB).

METHODS: Retreatment TB episodes between 2001 and 2010 in a high HIV and TB burden community were linked to first-episode treatment outcomes, HIV status and ART use. Genotypic analysis of Mycobacterium tuberculosis isolates distinguished re-infection from reactivation TB.

RESULTS: A total of 2027 TB episodes occurred in 1755 adults: 564 were retreatment cases. New patients who interrupted or failed initial treatment, were HIV-positive or were not on ART more frequently developed retreatment TB (respectively P < 0.001, P = 0.01 and P = 0.02). Time intervals between successive diagnoses were shorter in patients who interrupted/failed treatment compared to those with favourable initial treatment outcomes (P < 0.001), but did not vary by HIV status or ART use. Genotypic data were available for 40 successive diagnoses, of which 19 had matching M. tuberculosis strains. Matching strains were associated with HIV-negative status (P < 0.001), treatment interruption/failure (P = 0.04) and shorter intervals between diagnoses (P = 0.02). HIV-positive patients and patients on ART were more likely to have non-matched strains (P = 0.01 and P = 0.03).

CONCLUSION: Among HIV-negative patients, retreatment TB was predominantly due to reactivation following poor initial treatment outcomes. In HIV-positive patients re-infection TB was more common, particularly among those on ART.

Keywords: HIV; antiretroviral therapy; molecular epidemiology; re-infection; retreatment tuberculosis

Document Type: Research Article

DOI: http://dx.doi.org/10.5588/ijtld.12.0049

Affiliations: 1: Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Department of Medicine, University of Cape Town, Cape Town, South Africa 2: Public Health Research Institute TB Center, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA

Publication date: November 1, 2012

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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