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Free Content The knowns and unknowns of the immunopathogenesis of tuberculosis [State of the art]

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Abstract:

In this review, we discuss the ‘knowns’ and ‘unknowns’ of host defence towards Mycobacterium tuberculosis. With regard to the ‘knowns’, both protective and immunopathogenic mechanisms are discussed, including recently discovered new pathways of host defence and inflammatory immunopathology. With regard to the ‘unknowns’, there will be emphasis on unanswered key questions, accompanied by a perspective on needs and priorities for future research. The role of the inflammatory response and its dysregulation in tuberculosis-related immune reconstitution inflammatory syndrome will also be discussed.

Keywords: Mycobacterium tuberculosis; immunopathogenic mechanisms; immunopathology

Document Type: Research Article

DOI: https://doi.org/10.5588/ijtld.12.0479

Affiliations: Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

Publication date: 2012-11-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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