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Restricted spirometry in the Burden of Lung Disease Study

Authors: Mannino, D. M.1; McBurnie, M. A.2; Tan, W.3; Kocabas, A.4; Anto, J.5; Vollmer, W. M.2; Buist, A. S.6; on behalf of the BOLD Collaborative Research Group

Source: The International Journal of Tuberculosis and Lung Disease, Volume 16, Number 10, 1 October 2012 , pp. 1405-1411(7)

Publisher: International Union Against Tuberculosis and Lung Disease

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BACKGROUND: The presence of restrictive lung disease has classically required the measure of total lung capacity to document ‘true’ restriction, which has limited its detection in large population-based studies.

METHODS: We used spirometric data to classify people with restricted spirometry (forced expiratory volume in 1 second [FEV1]/forced vital capacity ≥ 0.70 and FEV1 < 80% predicted) in the Burden of Lung Disease (BOLD) Study and determined the relation between this finding and demographic factors and the presence of chronic diseases, including diabetes mellitus, hypertension and cardiovascular disease.

RESULTS: Overall, we found that 11.7% of men (546/4664) and 16.4% of women (836/5098) had restricted spirometry. Prevalence varied widely by site, from a low of 4.2% among males in Sydney, Australia, to a high of 48.7% among females in Manila, The Philippines. Compared to people with normal lung function, those with restricted spirometry had a higher prevalence of diabetes (12.2% vs. 4.6%), heart disease (15.0% vs. 7.7%) and hypertension (38.8% vs. 22.8%).

CONCLUSIONS: Restricted spirometry is a common finding in population studies. Additional research is needed to better define and describe the mechanisms that lead to restricted spirometry and potential interventions.

Keywords: cardiovascular disease; diabetes; restriction; spirometry; tobacco

Document Type: Research Article


Affiliations: 1: Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, Kentucky, USA 2: Kaiser Permanente Center for Health Research, Portland, Oregon, USA 3: University of British Columbia, Vancouver, British Columbia, Canada 4: Cukurova University School of Medicine, Adana, Turkey 5: Centre for Research in Environmental Epidemiology, Universitat Pompeu, Fabra, Spain 6: Oregon Health and Sciences University, Portland, Oregon, USA

Publication date: October 1, 2012

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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