Mycobacterium africanum, an emerging disease in high-income countries?
METHODS: We retrospectively reviewed TB cases due to M. africanum during 2000–2010 in seven Spanish hospitals. Selected clinical charts were reviewed using a predefined protocol that included demographical, clinical and microbiological data and outcome.
RESULTS: Although 57 cases were diagnosed, only 36 clinical charts were available for review: 82.8% were men and the mean age was 31.6 years (range 12–81). Forty-four cases were from Africa, 1 from the Philippines, 1 from India, and 4 from Spain, while the country of origin was unknown in 7 cases. The most frequent site of infection was the lung (58.3%). Four cases (6.9%) were resistant to at least one first-line anti-tuberculosis drug.
CONCLUSIONS: Disease due to M. africanum in industrialised countries is mainly associated with immigration from endemic areas, although some cases also occur among native-born populations.
Document Type: Research Article
Affiliations: 1: Department of Clinical Microbiology, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid, Spain 2: Hospital Virgen de la Concha, Zamora, Spain 3: Hospital de Don Benito-Villanueva de la Serena, Badajoz, Spain 4: Servicio de Microbiología y Parasitología, Hospital Universitario Miguel Servet, Zaragoza, Spain 5: Hospital Universitario Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, Spain 6: Unidad de Referencia Regional de Micobacterias, Hospital Universitario Central de Asturias, Oviedo, Spain 7: Hospital Universitario Son Dureta, Palma de Mallorca, Spain 8: Hospital Infanta Cristina de Badajoz, Badajoz, Spain 9: Hospital San Pedro de Alcántara, Cáceres, Spain 10: Servicio de Microbiología, Hospital Universitario ‘Lozano Blesa’, Zaragoza, Spain
Publication date: 2012-10-01
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