Tuberculosis caused by RDRio Mycobacterium tuberculosis is not associated with differential clinical features
OBJECTIVE: To determine the association of differential clinical features of pulmonary TB with the RDRio M. tuberculosis etiology.
METHODS: Culture-proven pulmonary TB patients (n = 272) were clinically evaluated, including history, physical examination, chest X-ray and anti-human immunodeficiency virus serology. Isolates were classified as RDRio or non-RDRio M. tuberculosis by multiplex polymerase chain reaction and further spoligotyped. Clinical and M. tuberculosis genotype data were analyzed.
RESULTS: RDRio M. tuberculosis caused disease in 26.5% (72/270) of all TB cases. The LAM genotype, of which RDRio strains are members, was responsible for 46.0% of the TB cases. Demographic data, major signs and symptoms, radiographic presentation, microbiological features and clinical outcomes were not significantly different among patients with TB caused by RDRio and non-RDRio strains.
CONCLUSIONS: Disease caused by M. tuberculosis RDRio strains was not clinically distinctive or more severe than disease caused by non-RDRio strains in this series of TB patients. Larger prospective studies specifically designed to disclose differential clinical characteristics of TB caused by specific M. tuberculosis lineages are needed.
Document Type: Research Article
Affiliations: 1: Multidisciplinary Research Laboratory, Clementino Fraga Filho University Hospital, Institute of Thoracic Diseases, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil 2: Laboratory of Applied Molecular Biology to Mycobacteria, Oswaldo Cruz Institute, Rio de Janeiro, Rio de Janeiro, Brazil 3: Tuberculosis Control Program, Clementino Fraga Filho University Hospital, Institute of Thoracic Diseases, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil 4: Mycobacteriology Laboratory, Instituto de Microbiologia, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil 5: Tuberculosis Academic Program, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil 6: Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, New York, USA; and Centers for Disease Control in Haiti, Dulles, Virginia, USA
Publication date: 2012-10-01
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