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Outcomes of HIV-infected patients treated for recurrent tuberculosis with the standard retreatment regimen

Authors: McGreevy, J.1; Jean Juste, M. A.1; Severe, P.1; Collins, S.2; Koenig, S.3; Pape, J. W.4; Fitzgerald, D. W.2

Source: The International Journal of Tuberculosis and Lung Disease, Volume 16, Number 6, 1 June 2012 , pp. 841-845(5)

Publisher: International Union Against Tuberculosis and Lung Disease

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Abstract:

SETTING: The Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (the GHESKIO AIDS and TB Center) in Port-au-Prince, Haiti.

OBJECTIVE: To measure the effectiveness of the standard TB retreatment regimen (2HRZES/1HRZE/5HRE) in human immunodeficiency virus (HIV) infected adults.

DESIGN: Cohort study.

RESULTS: Of 1318 HIV-infected patients with access to antiretroviral therapy following World Health Organization guidelines, 56 were diagnosed with recurrent pulmonary TB and retreated with the standard retreatment regimen: 10 patients (18%) died during retreatment, 3 (5%) defaulted, and 2 (4%) failed treatment. Forty-one patients (73%) achieved retreatment ‘success’ (cure, treatment completed). Of these, 8 (20%) died during follow-up, 5 (12%) were lost, and 5 (12%) had a second recurrence of TB. Only 26 (46%) of the 56 patients remained alive, in care, and TB-free after a median of 36 months of follow-up.

CONCLUSION: HIV-infected patients treated for recurrent TB with the standard retreatment regimen have high mortality and poor long-term outcomes.

Keywords: human immunodeficiency virus; retreatment; tuberculosis

Document Type: Research Article

DOI: http://dx.doi.org/10.5588/ijtld.11.0210

Affiliations: 1: Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port au Prince, Haiti 2: Department of Medicine, Weill Cornell Medical College, New York, New York, USA 3: Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA 4: Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port au Prince, Haiti; Department of Medicine, Weill Cornell Medical College, New York, New York, USA

Publication date: June 1, 2012

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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