Diagnostic sensitivity of culture and drug resistance patterns in Korean patients with intestinal tuberculosis
OBJECTIVE: To determine the diagnostic sensitivity of a culture assay using colonoscopic biopsy specimens and the drug resistance patterns of Mycobacterium tuberculosis isolated from ITB.
DESIGN: Data from 400 patients diagnosed with ITB were retrospectively analysed.
RESULTS: Of the 400 patients, 170 (42.5%) were males; the median age at diagnosis was 40 years. The sensitivity of culture was 44.1% (145/329). Resistance to at least one anti-tuberculosis drug was identified in 13 (17.6%) and multidrug-resistant TB (MDR-TB) was diagnosed in two (2.7%) of the 74 patients for whom drug susceptibility testing was performed. Including M. tuberculosis isolated from respiratory specimens, the proportion of MDR-TB was 4.4% (5/113); previous anti-tuberculosis treatment was an independent risk factor for MDR-TB (26.7% vs. 1.0%, P < 0.01).
CONCLUSION: Culture of colonoscopic biopsy specimens shows substantial diagnostic sensitivity; the frequency of MDR-TB is higher in previously treated cases than in new cases.
Document Type: Research Article
Affiliations: 1: Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea 2: Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea 3: Department of Infectious Diseases, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea 4: Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea 5: Division of Gastroenterology, Department of Internal Medicine, Eulji University College of Medicine, Daejeon, Korea
Publication date: 01 June 2012
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