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Vaccination of mice with recombinant bacille Calmette-Guérin harboring Rv1357c protects similarly to native BCG [Short communication]

Authors: Flores-Valdez, M. A.1; de Jesús Aceves-Sánchez, M.1; Montero-Pérez, S. A.1; Sánchez-López, A. D.2; Gutiérrez-Pabello, J. A.2; Hernández-Pando, R.3

Source: The International Journal of Tuberculosis and Lung Disease, Volume 16, Number 6, 1 June 2012 , pp. 774-776(3)

Publisher: International Union Against Tuberculosis and Lung Disease

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Abstract:

Despite the availability of a Mycobacterium bovis bacille Calmette Guérin (BCG) vaccine, tuberculosis (TB) remains a global public health problem. In this study, we introduced the c-di-GMP phosphodiesterase gene Rv1357c, implicated in regulating mycobacterial replication within macrophages, into BCG Pasteur, and tested the resulting strain for its capacity to serve as a vaccine against TB in a murine model. Modified BCG was more phagocytosed than its parental strain, but halted bacterial replication, and protected against M. tuberculosis challenge similarly to unmodified BCG.

Keywords: c-di-GMP; tuberculosis; vaccine

Document Type: Research Article

DOI: http://dx.doi.org/10.5588/ijtld.11.0735

Affiliations: 1: Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, Guadalajara, Jalisco, Mexico 2: Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico City, Mexico 3: Instituto Nacional de la Nutrición y Ciencias Médicas Salvador Zubirán, Mexico City, Mexico

Publication date: June 1, 2012

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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