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Free Content Is isoniazid for 6 months more cost-effective than isoniazid for 9 months?

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Abstract:

SETTING: The optimal treatment for latent tuberculosis infection consists of isoniazid (H, INH) for 9–12 months. Although INH for 6 months (6H) is more cost-effective than the 12-month regimen, the cost-effectiveness of the 6H regimen and that of INH for 9 months (9H) have not been compared.

OBJECTIVE: To compare the cost-effectiveness of treatment with 6H and 9H.

METHODS: Cost-effectiveness was evaluated using the ratio of the cost of preventing one tuberculosis case using 6H vs. 9H. The cost was estimated as the product of the number of patients to be treated to prevent one case using 6H or 9H × the cost of 6H or 9H.

RESULTS: A total of 1039 patients were studied. The number of patients that needed to be treated to prevent one case was 33 (95%CI 21–83) using 6H and 26 (95%CI 18–50) using 9H. The cost of 6H and 9H was respectively €444.34 and €578.26, and the cost ratio of preventing one case with 6H/9H was 0.98 (95%CI 0.6–1.5).

CONCLUSIONS: The cost-effectiveness of treatment with 6H and 9H is similar.

Keywords: cost-effectiveness; isoniazid; treatment; tuberculosis infection

Document Type: Research Article

DOI: https://doi.org/10.5588/ijtld.11.0302

Affiliations: 1: Catalan Institute of Health, Department of Health, Generalitat of Catalonia, Barcelona, Spain; Epidemiological Surveillance Unit, Tuberculosis Control Programme, Central Region of Catalonia, Department of Health, Generalitat of Catalonia, Barcelona, Spain 2: Catalan Institute of Health, Department of Health, Generalitat of Catalonia, Barcelona, Spain; Epidemiological Surveillance Unit, Tuberculosis Control Programme, Central Region of Catalonia, Department of Health, Generalitat of Catalonia, Barcelona, Spain 3: Epidemiological Surveillance Unit, Central Region of Catalonia, Department of Health, Generalitat of Catalonia, Barcelona, Spain 4: Epidemiological Surveillance Unit, Tuberculosis Control Programme, Central Region of Catalonia, Department of Health, Generalitat of Catalonia, Barcelona, Spain 5: Department of Public Health, University of Barcelona, Barcelona, Spain; CIBER Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain

Publication date: 2012-06-01

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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