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Free Content The challenges of replicating the methodology between Phases I and III of the ISAAC programme

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Abstract:

BACKGROUND: The International Study of Asthma and Allergies in Childhood (ISAAC) used standardised methods to examine symptom prevalence of asthma, rhinitis and eczema in adolescents and children between Phases I and III. Centres followed essential rules to ensure comparability of methodology, examined by a centralised data centre.

METHODS: Centre reports (CRs) were compared for both phases and age groups. Methodological differences were categorised under major deviations (centres excluded), minor deviations (deviations identified in published tables) and very minor deviations (deviations not identified).

RESULTS: There were 112 CRs for adolescents and 70 for children. Six centres for adolescents and four for children had major deviations and were excluded. Minor deviations (35 for adolescents and 20 for children) were identified in the publications. Very minor deviations (92 for adolescents and 51 for children) were not identified. The odds ratios for having any differences in methodology between phases with a change in Principal Investigator were 0.80 (95%CI 0.36–1.81) for adolescents and 0.91 (95%CI 0.32–2.62) for children.

CONCLUSION: The majority of the centres replicated the ISAAC methodology to a high standard. Careful documentation of methodology using standardised tools with careful checks allows the full potential of studies such as ISAAC to be realised.

Keywords: ISAAC; adolescents; children; methodology; replication

Document Type: Research Article

DOI: https://doi.org/10.5588/ijtld.11.0226

Affiliations: 1: Department of Paediatrics: Child and Youth Health, The University of Auckland, Auckland, New Zealand 2: School of Population Health, The University of Auckland, Auckland, New Zealand 3: International Union Against Tuberculosis and Lung Disease, Paris, France 4: Department of Paediatric Respiratory Medicine, Hospital Centro de Referencia de Salud El Pino, University of Santiago de Chile, Santiago, Chile 5: Division of Community Health Sciences, St George's, University of London, London, UK

Publication date: 2012-05-01

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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