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Free Content Interleukin-10 and interferon-gamma patterns during tuberculosis treatment: possible association with recurrence [Short communication]

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Abstract:

Interleukin (IL) 10 and interferon-gamma (IFN-) levels in induced sputum supernatants of 21 tuberculosis (TB) patients at diagnosis and during chemotherapy were correlated to recurrence rates. IL-10 decreased until day 60 of treatment (T60), and between T60 and T180 it increased again in 7 cases (Pattern 1) and further decreased in 14 cases (Pattern 2). Follow-up of 69 months was performed in 20/21 cases; 6 had recurrence of TB, of which 5/7 (71%) had Pattern 1 and 1/13 (7.7%) Pattern 2 (OR 30.0, 95%CI 2.19411.3, P 0.0072). This was not observed for IFN-. High IL-10 levels at the end of treatment may function as a risk factor for TB recurrence.

Keywords: IFN-γ; IL-10; induced sputum; recurrence; tuberculosis

Document Type: Research Article

DOI: http://dx.doi.org/10.5588/ijtld.11.0707

Affiliations: 1: Multidisciplinary Laboratory, Clementino Fraga Filho University Hospital, Institute of Thoracic Diseases, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil 2: Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, New York, USA; Centers for Disease Control in Haiti, Dulles, Virginia, USA 3: Multidisciplinary Laboratory, Clementino Fraga Filho University Hospital, Institute of Thoracic Diseases, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil; Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, New York, USA

Publication date: May 1, 2012

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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