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Population-based surveillance of extensively drug-resistant tuberculosis in Shandong Province, China [Short communication]

Authors: Li, X.1; Wang, H.1; Jing, H.1; Wang, Y.1; Yu, C.1; Wang, J.1; Liu, Z.1; Graviss, E. A.2; Ma, X.3

Source: The International Journal of Tuberculosis and Lung Disease, Volume 16, Number 5, 1 May 2012 , pp. 612-614(3)

Publisher: International Union Against Tuberculosis and Lung Disease

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Abstract:

To investigate the prevalence of extensively drug-resistant tuberculosis (XDR-TB) in Chinese populations, we analyzed the drug resistance profiles of 1787 Mycobacterium tuberculosis isolates through a population-based surveillance project in Shandong Province, China. We found 330 (18.5%; 95%CI 16.1–20.3) isolates resistant to ≥1 first-line drug and 65 (3.6%; 95%CI 2.9–4.6) multidrug-resistant (MDR) isolates, of which 13 (20.0%; 95%CI 11.9–31.4) were XDR; 47/65 MDR-TB isolates (70.8%; 95%CI 58.2–81.4) were resistant to fluoroquinolones. Our results indicate that inadequate application of second-line anti-tuberculosis drugs has caused increased prevalence of XDR-TB in certain Chinese populations.

Keywords: Mycobacterium tuberculosis; extensively drug-resistant tuberculosis; multidrug-resistant tuberculosis

Document Type: Research Article

DOI: http://dx.doi.org/10.5588/ijtld.11.0507

Affiliations: 1: Katharine Hsu International Research Center of Human Infectious Diseases, Shandong Provincial Chest Hospital, Jinan, China 2: Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, USA 3: Katharine Hsu International Research Center of Human Infectious Diseases, Shandong Provincial Chest Hospital, Jinan, China; Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, USA

Publication date: May 1, 2012

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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