Population-based surveillance of extensively drug-resistant tuberculosis in Shandong Province, China [Short communication]
Abstract:To investigate the prevalence of extensively drug-resistant tuberculosis (XDR-TB) in Chinese populations, we analyzed the drug resistance profiles of 1787 Mycobacterium tuberculosis isolates through a population-based surveillance project in Shandong Province, China. We found 330 (18.5%; 95%CI 16.1–20.3) isolates resistant to ≥1 first-line drug and 65 (3.6%; 95%CI 2.9–4.6) multidrug-resistant (MDR) isolates, of which 13 (20.0%; 95%CI 11.9–31.4) were XDR; 47/65 MDR-TB isolates (70.8%; 95%CI 58.2–81.4) were resistant to fluoroquinolones. Our results indicate that inadequate application of second-line anti-tuberculosis drugs has caused increased prevalence of XDR-TB in certain Chinese populations.
Document Type: Research Article
Affiliations: 1: Katharine Hsu International Research Center of Human Infectious Diseases, Shandong Provincial Chest Hospital, Jinan, China 2: Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, USA 3: Katharine Hsu International Research Center of Human Infectious Diseases, Shandong Provincial Chest Hospital, Jinan, China; Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas, USA
Publication date: 2012-05-01
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