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Free Content Fluoroquinolone and pyrazinamide resistance in multidrug-resistant tuberculosis [Short communication]

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In a study performed in Cambodia, a higher number of tuberculosis (TB) strains with mutations in the pncA gene associated with pyrazinamide resistance (PZA-R) was found in fluoroquinolone-resistant (FQ-R) multidrug-resistant (MDR) strains (93%), compared with 47% in MDR and 3% in non-MDR strains. This emphasises the need for easy and rapid tests for identification of PZA-R for efficient treatment of MDR-TB.

Keywords: MDR-TB; fluoroquinolone; pyrazinamide

Document Type: Research Article


Affiliations: 1: Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France 2: Mycobacteriology Laboratory, Institut Pasteur in Cambodia, Phnom Penh, Cambodia

Publication date: 2012-02-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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