Free Content DOT associated with reduced all-cause mortality among tuberculosis patients in Taipei, Taiwan, 2006–2008

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Abstract:

OBJECTIVE: To determine whether patients receiving directly observed treatment (DOT) had lower all-cause mortality than those treated with self-administered treatment (SAT) and to identify factors associated with mortality among tuberculosis (TB) patients.

DESIGN: All TB patients in Taipei, Taiwan, diagnosed between 2006 and 2008 were included in a retrospective cohort study.

RESULTS: Among 3624 TB patients, 45.5% received DOT, which was disproportionately offered to older patients and those with more underlying illness and severe TB disease. After controlling for patients' sociodemographic factors, clinical findings and underlying comorbidities, the odds of death were 40% lower (aOR 0.60, 95%CI 0.5–0.8) among patients treated with DOT than those on SAT. After adjusting for DOT, independent predictors of death included non-Taiwan birth, increasing age, male, unemployment, end-stage renal disease requiring dialysis, malignancy, acid-fast bacilli smear positivity and pleural effusion.

CONCLUSION: DOT was associated with lower all-cause mortality after controlling for confounding factors. DOT should be expanded in Taiwan to improve critical treatment outcomes among TB patients.

Keywords: directly observed therapy; mortality; treatment; tuberculosis

Document Type: Research Article

DOI: http://dx.doi.org/10.5588/ijtld.11.0034

Affiliations: 1: Section of Infectious Diseases, Taipei City Hospital, Taipei City Government, Taipei, Taiwan; Division of Global Public Health, University of California San Diego, San Diego, CA, USA 2: Division of Global Public Health, University of California San Diego, San Diego, CA, USA 3: Department of Disease Control and Prevention, Taipei City Hospital, Taipei City Government, Taipei, Taiwan 4: Section of Infectious Diseases, Taipei City Hospital, Taipei City Government, Taipei, Taiwan

Publication date: February 1, 2012

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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