CCL2−2518 (A/G) polymorphisms and tuberculosis susceptibility: a meta-analysis [Review article]
Abstract:BACKGROUND: It has been found that the −2518 C-C motif ligand (CCL)-2 promoter variant increases the risk of developing active tuberculosis (TB).
OBJECTIVE: To study the association between −2518 variants and susceptibility to TB.
DESIGN: We searched Medline, PubMed and the Wan Fang databases for human genetic studies on whether the −2518 CCL2 polymorphism influences the expression of active TB. Articles published from January 1998 to November 2010 were included. A random effects model was conducted in the meta-analysis.
RESULTS: The CCL2−2518G allele (OR 1.51, 95%CI 1.11–2.04, P = 0.008) showed significant association with susceptibility to TB. In genotype analysis, the recessive model (CCL2 genotype GG, OR 1.66, 95%CI 1.19–2.33, P = 0.003) was slightly superior to the dominant model (G carrier genotypes OR 1.53, 95%CI 1.07–2.17, P = 0.018). These observations were prominent among Asians and Latin-Americans of Hispanic ancestry, but not in Africans from Ghana and South Africa. The presence of epistatic genes in one population but not in the other, environmental differences and pathogen virulence may account for this.
CONCLUSION: The CCL2−2518G allele increases the risk of developing TB in Asians and Hispanics.
Document Type: Research Article
Affiliations: 1: National Key Discipline of Paediatrics (Capital Medical University), Ministry of Education, Key Laboratory of Major Diseases in Children (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital affiliated to Capital Medical University, Beijing, China 2: The Methodist Hospital Research Institute, The Methodist Hospital, Houston, Texas, USA 3: Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia 4: National Institute on Drug Dependence, Peking University, Beijing, China
Publication date: February 1, 2012
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