Mycobacterium tuberculosis and non-tuberculous mycobacteria isolates from HIV-infected patients in Guangxi, China
OBJECTIVE: To estimate the prevalence of M. tuberculosis and NTM in HIV-infected patients in Guangxi Province, determine their drug resistance profiles, and evaluate the genotype patterns of M. tuberculosis strains.
DESIGN: Samples were collected from two HIVd esignated hospitals in Guangxi Province between 2005 and 2008. HIV-infected patients who were culturep ositive for mycobacteria were included. Drug susceptibility testing was performed for mycobacterial isolates. NTM species was identified by sequencing, and M. tuberculosis isolates were genotyped using the variable number of tandem repeats method.
RESULTS: M. tuberculosis and NTM were identified in respectively 117 (53%) and 102 (47%) HIV-infected patients. Drug resistance was found in 27% and multi- drug-resistant TB (MDR-TB) in 11% of the patients with TB. Previous treatment for TB was significantly as- sociated with MDR-TB. Twenty (17%) TB patients be- longed to eight VNTR-defined clusters.
CONCLUSION: The high frequency of NTM among HIV-infected patients raises concerns about accurate species identification before the determination of appropriate treatment. The potential for TB transmission exists among HIV-infected patients. Intensified screening and effective treatment of TB-HIV co-infected patients is urgently needed.
Document Type: Research Article
Affiliations: 1: Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, Guangxi, China 2: Institute of Biomedical Sciences, Key Laboratory of Medical Molecular Virology and Institute of Medical Microbiology, Fudan University, Shanghai, China
Publication date: 2011-12-01
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