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Free Content Adherence to isoniazid preventive therapy in children exposed to tuberculosis: a prospective study from Guinea-Bissau

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OBJECTIVE: To assess adherence to isoniazid preven- tive therapy (IPT) in children exposed to adult pulmo- nary tuberculosis (TB) at home.

METHODS: Children were enrolled on IPT if they were aged ≤5 years or 5–15 years and presented a tuberculin skin test induration of ≥10 mm. Children were included from the demographic surveillance system of the Bandim Health Project in Bissau, Guinea-Bissau. The main outcome measures were adherence, completion rates and side effects during 9 months of IPT. The main outcome was 6 consecutive months of at least 80% adherence.

RESULTS: A total of 2631 children were identified as contacts of adult TB cases. Among the children identi- fied, 1895 (72%) were evaluated for eligibility for IPT, and 820 were enrolled in the study: 609 were aged ≤5 years and 211 aged 5–15 years. A total of 79% of the prescribed doses were taken, with 65% of the children taking > 80% of their doses. In all, 51% completed more than 6 consecutive months of IPT.

CONCLUSION: Overall adherence to IPT was better than previously reported from TB-endemic areas, with 76% of the children completing at least 6 months of treatment, with more than 80% adherence.
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Keywords: ADHERENCE; GUINEA-BISSAU; ISONIAZID PREVENTIVE THERAPY; LATENT TB; TB EXPOSURE

Document Type: Research Article

Affiliations: 1: Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau 2: Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark 3: National Tuberculosis Referral Hospital (Hospital de Pneumologia Raoul Follereau), Bissau 4: Hospital Nacional Simao Mendes, Bissau, Guinea-Bissau 5: Infectious Diseases Research Group, Department of Clinical Sciences, Lund University, Malmö, Sweden

Publication date: 01 December 2011

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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