Multidrug-resistant tuberculosis is associated with low plasma concentrations of human neutrophil peptides 1–3
Abstract:SETTING: Human neutrophil peptides 1, 2 and 3 (HNP1-3) are involved in innate host defence and acquired immune response, which is possibly associated with the genesis of multidrug-resistant tuberculosis (MDR-TB).
OBJECTIVE: To investigate the relationship between HNP1-3 and MDR-TB.
DESIGN: We divided 42 patients with post-primary pulmonary TB into two groups according to their drug susceptibility test results: the drug-susceptible group (n = 21) and the MDR-TB group (n = 21). The concentration of HNP1-3 in the plasma of all specimens was measured by enzyme-linked immunosorbent assay before treatment and 6, 18 and 24 months after. Duration of Mycobacterium tuberculosis in sputum and peripheral blood neutrophil counts were measured at the same time.
RESULTS: Before treatment, the plasma HNP1-3 concentration in the MDR-TB group was lower than that of healthy controls and the drug-susceptible group. After treatment, plasma HNP1-3 concentrations were higher than pre-treatment levels in the MDR-TB group, but were still lower than in healthy controls or the drug-susceptible group. The concentration of HNP1-3 was negatively correlated with the duration of M. tuberculosis in sputum, while it was positively correlated with neutrophils.
CONCLUSION: MDR-TB is associated with low plasma concentrations of HNP1-3.
Document Type: Regular Paper
Affiliations: 1: Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China 2: Department of Respiratory Medicine, Hunan Geriatric Hospital, Changsha, Hunan, People's Republic of China 3: Department of Thoracic Medicine, Changsha Central Hospital, Changsha, Hunan, People's Republic of China
Publication date: March 1, 2011
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