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Free Content Multidrug-resistant tuberculosis is associated with low plasma concentrations of human neutrophil peptides 1–3

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Abstract:

SETTING: Human neutrophil peptides 1, 2 and 3 (HNP1-3) are involved in innate host defence and acquired immune response, which is possibly associated with the genesis of multidrug-resistant tuberculosis (MDR-TB).

OBJECTIVE: To investigate the relationship between HNP1-3 and MDR-TB.

DESIGN: We divided 42 patients with post-primary pulmonary TB into two groups according to their drug susceptibility test results: the drug-susceptible group (n = 21) and the MDR-TB group (n = 21). The concentration of HNP1-3 in the plasma of all specimens was measured by enzyme-linked immunosorbent assay before treatment and 6, 18 and 24 months after. Duration of Mycobacterium tuberculosis in sputum and peripheral blood neutrophil counts were measured at the same time.

RESULTS: Before treatment, the plasma HNP1-3 concentration in the MDR-TB group was lower than that of healthy controls and the drug-susceptible group. After treatment, plasma HNP1-3 concentrations were higher than pre-treatment levels in the MDR-TB group, but were still lower than in healthy controls or the drug-susceptible group. The concentration of HNP1-3 was negatively correlated with the duration of M. tuberculosis in sputum, while it was positively correlated with neutrophils.

CONCLUSION: MDR-TB is associated with low plasma concentrations of HNP1-3.

Keywords: Mycobacterium tuberculosis; human neutrophil peptides 1, 2 and 3 (HNP1-3); multidrug-resistant; neutrophil; pulmonary tuberculosis

Document Type: Regular Paper

Affiliations: 1: Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China 2: Department of Respiratory Medicine, Hunan Geriatric Hospital, Changsha, Hunan, People's Republic of China 3: Department of Thoracic Medicine, Changsha Central Hospital, Changsha, Hunan, People's Republic of China

Publication date: March 1, 2011

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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