Management of young children in contact with an adult with drug-resistant tuberculosis, France, 2004–2008
Abstract:SETTING: Drug-resistant tuberculosis (DR-TB) is increasing worldwide and may be a source of diagnostic and therapeutic problems in young exposed children. In France exposed children are systematically treated with 3-month isoniazid-rifampicin prophylaxis.
OBJECTIVE: To describe the characteristics and management of children aged <2 years in contact with an adult case of DR-TB in France over a 5-year period (2004–2008).
METHODS: Children were retrospectively identified by sending questionnaires to all the members of the Paediatric Infectious Diseases Group and the Paediatric Pulmonology Group of the French Paediatric Society.
RESULTS: Ten children, all infants, in contact with an adult case of DR-TB were identified: six cases of DR-TB (mean age 4.6 months), one case of TB infection and three cases of exposure (mean age 3.1 months). The children were mainly in contact with poly- or multidrug-resistant TB. Time to initiation of appropriate treatment was 39 days for TB disease and 58 days for TB infection or exposure. One child with TB infection developed TB disease due to failure to adapt prophylaxis. Treatment was variable and centre-dependent. Short-term follow-up showed complete recovery of all children.
CONCLUSION: Management of young children in contact with adult DR-TB requires rapid identification of the drug resistance profile. Molecular techniques should be used to reduce delays in initiating appropriate treatment.
Document Type: Regular Paper
Affiliations: 1: Paediatric Unit, Centre Hospitalièr Universitaire Timone-Enfants, Marseille, France 2: Paediatric Unit, Centre Hospitalièr Universitaire Timone-Enfants, Marseille, France; and Paediatric Unit, Centre Hospitalièr, Toulon, France 3: Paediatric Unit, Centre Hospitalièr Universitaire Rennes, Rennes, France 4: Paediatric Unit, Hôpital Trousseau, Paris, France 5: Paediatric Unit, Centre Hospitalièr St Brieuc, St Brieuc, France 6: Paediatric Unit, Hôpital Jean Verdier, Bondy, France 7: Paediatric Unit, Centre Hospitalièr Felix Guyon, St Denis, France 8: Paediatric Unit, Centre Hospitalièr Universitaire Montpellier, Montpellier, France 9: National Centre for Mycobacteria and Drug-Resistant Tuberculosis, La Pitié Salpêtrière, Paris, France
Publication date: March 1, 2011
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