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Free Content Low agreement between the T-SPOT®.TB assay and the tuberculin skin test among college students in China [Short communication]

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Abstract:

T-SPOT®.TB and the tuberculin skin test (TST) were used to screen for latent tuberculosis infection among 899 Chinese college students. The positivity rates for T-SPOT®.TB and TST were respectively 13.0% (95% confidence interval [CI] 10.4–15.9) and 24.9% (95%CI 21.5–28.6) among students with a bacille Calmette-Guérin (BCG) scar (agreement of both tests 72.3%; 95%CI 68.6–75.8; κ = 0.118), and respectively 17.3% (95%CI 11.7–24.2) and 23.7% (95%CI 17.3–31.2) among those without a BCG scar (agreement 73.1%; 95%CI 65.4–79.9; κ = 0.179). These results demonstrate low agreement between the TST and T-SPOT.TB in the Chinese population studied.

Keywords: IFN-γ; T-SPOT®.TB; latent tuberculosis infection; tuberculin skin test

Document Type: Short Communication

Affiliations: 1: Department of Laboratory Medicine, Jinan Sixth Hospital, Zhangqiu, China 2: Department of Laboratory Medicine, Jinan Central Hospital, Jinan, China 3: Katharine Hsu International Research Center of Human Infectious Diseases, Shandong Provincial Chest Hospital, Jinan, China 4: Qilu Hospital, Shandong University, Jinan, China 5: The Methodist Hospital Research Institute, Houston, Texas, USA 6: Katharine Hsu International Research Center of Human Infectious Diseases, Shandong Provincial Chest Hospital, Jinan, China; The Methodist Hospital Research Institute, Houston, Texas, USA

Publication date: 2011-01-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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