Low agreement between the T-SPOT®.TB assay and the tuberculin skin test among college students in China [Short communication]
Abstract:T-SPOT®.TB and the tuberculin skin test (TST) were used to screen for latent tuberculosis infection among 899 Chinese college students. The positivity rates for T-SPOT®.TB and TST were respectively 13.0% (95% confidence interval [CI] 10.4–15.9) and 24.9% (95%CI 21.5–28.6) among students with a bacille Calmette-Guérin (BCG) scar (agreement of both tests 72.3%; 95%CI 68.6–75.8; κ = 0.118), and respectively 17.3% (95%CI 11.7–24.2) and 23.7% (95%CI 17.3–31.2) among those without a BCG scar (agreement 73.1%; 95%CI 65.4–79.9; κ = 0.179). These results demonstrate low agreement between the TST and T-SPOT.TB in the Chinese population studied.
Document Type: Short Communication
Affiliations: 1: Department of Laboratory Medicine, Jinan Sixth Hospital, Zhangqiu, China 2: Department of Laboratory Medicine, Jinan Central Hospital, Jinan, China 3: Katharine Hsu International Research Center of Human Infectious Diseases, Shandong Provincial Chest Hospital, Jinan, China 4: Qilu Hospital, Shandong University, Jinan, China 5: The Methodist Hospital Research Institute, Houston, Texas, USA 6: Katharine Hsu International Research Center of Human Infectious Diseases, Shandong Provincial Chest Hospital, Jinan, China; The Methodist Hospital Research Institute, Houston, Texas, USA
Publication date: 2011-01-01
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