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Free Content Strain classification of Mycobacterium tuberculosis: congruence between large sequence polymorphisms and spoligotypes [Short communication]

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Spoligotyping is used in molecular epidemiological studies, and signature patterns have identified strain families. However, homoplasy occurs in the markers used for spoligotyping, which could lead to identical spoligotypes in phylogenetically unrelated strains. We determined the accuracy of strain classification based on spoligotyping using the six large sequence and single nucleotide polymorphisms-defined lineages as a gold standard. Of 919 Mycobacterium tuberculosis isolates, 870 (95%) were classified into a spoligotype family. Strains from a particular spoligotype family belonged to the same lineage. We did not find convergence to the same spoligotype. Spoligotype families appear to be sub-lineages within the main lineages.
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Keywords: Mycobacterium tuberculosis; genotype; large sequence polymorphism; spoligotyping; strain classification

Document Type: Short Communication

Affiliations: 1: Francis J Curry National Tuberculosis Center, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, Department of Medicine University of California San Francisco, San Francisco, California, USA 2: Medical Research Council National Institute for Medical Research, London, UK; Swiss Tropical and Public Health Institute, Basel, Switzerland; and University of Basel, Basel, Switzerland 3: Bill and Melinda Gates Foundation, Seattle, Washington, USA 4: Microbial Diseases Laboratory, California Department of Public Health, Richmond, California, USA

Publication date: 2011-01-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

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